Sunday 6 May 2018

Haloperidol for cannabinoid hyperemesis syndrome; why not…

It seems “Vitamin H” is pretty good for lots of things.

Add it to the list for cannabinoid hyperemesis syndrome (CHS)!

Ok, this “study” if far from high science (forgive the pun). It’s a retrospective chart review reporting a case series of 4 with lots of limitations.

All included patients were thought to have CHS. Perhaps they were diagnosed in the hot shower? They seemed to all have refractory vomiting until they were given haloperidol 5mg IV.

The authors provide some physiologic reasons why this might be efficacious and appropriately temper their conclusion by stating their success “warrants further investigation.”

In summary, this study is arguably a level of evidence just above anecdote. But who cares… did I say I love vitamin H?


Witsil JC, Mycyk MB. Haloperidol, A Novel Treatment for Cannabinoid Hyperemesis Syndrome. Am J Therap. 2017;24:e64-7.

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